Overview

  • Product name

    Tioconazole, cytochrome-P450 inhibitor
  • Description

    Imidazole antifungal agent, cytochrome-P450 inhibitor
  • Biological description

    Imidazole antifungal agent, cytochrome-P450 inhibitor. Shows broad spectrum of activity.
  • CAS Number

    65899-73-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • Molecular weight

    387.71
  • Molecular formula

    C16H13Cl3N2OS
  • PubChem identifier

    5482
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C(=CC=C1Cl)C(OCC2C=CSC=2Cl)CN3C=CN=C3)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Latrille F  et al. Effects of tioconazole on parturition and serum levels of 17 beta-oestradiol, progesterone, LH and PRL in the rat. Biochem Pharmacol 36:1119-24 (1987). Read more (PubMed: 3566806) »
  • Jevons S  et al. Antifungal activity of tioconazole (UK-20,349), a new imidazole derivative. Antimicrob Agents Chemother 15:597-602 (1979). Read more (PubMed: 464592) »
  • Macrae PV  et al. Characterization of a quaternary, N-glucuronide metabolite of the imidazole antifungal, tioconazole. Drug Metab Dispos 18:1100-2 (0). Read more (PubMed: 1981520) »

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