Overview

  • Product name

    Tiotropium Bromide, M1, M2 and M3 antagonist
  • Description

    Highly potent, long-acting M1, M2 and M3 antagonist
  • Biological description

    Highly potent, long-acting M1, M2 and M3 antagonist. Induces smooth muscle relaxation and bronchodilation (IC50 = 0.17 nM) in vivo.
  • Purity

    > 99%
  • CAS Number

    136310-93-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-((Hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide
  • Molecular weight

    472.42
  • Molecular formula

    C19H22BrNO4S2
  • PubChem identifier

    5487426
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Smit M  et al. Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a Guinea pig model of allergic asthma. J Pharmacol Exp Ther 348:303-10 (2014). Read more (PubMed: 24307202) »
  • Meurs H  et al. Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target. Pulm Pharmacol Ther 26:145-55 (2013). Read more (PubMed: 22842340) »
  • Takahashi T  et al. Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am J Respir Crit Care Med 150:1640-5 (1994). Read more (PubMed: 7952627) »

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