Key features and details
- Mouse polyclonal to TIPE2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TIPE2 antibody
See all TIPE2 primary antibodies
DescriptionMouse polyclonal to TIPE2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Cow, Baboon
Full length protein corresponding to Human TIPE2 aa 1-184.
MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYT HSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMT ALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHF SDPGLLTALYGPDFTQHLGKICDGLRKLLDEGKL
Database link: AAH63014
- WB: TIPE2 transfected HEK-293T cell lysate.
Protein previously known as Tumor necrosis factor alpha-induced protein 8-like protein 2.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab169616 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa.|
FunctionActs as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
Sequence similaritiesBelongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
DomainThe central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
- Information by UniProt
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ab169616 has been referenced in 1 publication.
- He B et al. Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice. Mol Med Rep 16:6013-6019 (2017). PubMed: 28849138