Overview

  • Product name

    Tiratricol (TRIAC), Thyroid hormone analog
  • Description

    Thyroid hormone analog
  • Alternative names

    • TRIAC
  • Biological description

    Thyroid hormone analog. Shows hepatoselectivity. Suppresses thyroid-stimulating hormone production and shows antiobesogenic effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    51-24-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
  • Molecular weight

    621.93
  • Molecular formula

    C14H9I3O4
  • PubChem identifier

    5803
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Senese R  et al. Thyroid: biological actions of 'nonclassical' thyroid hormones. J Endocrinol 221:R1-12 (2014). Read more (PubMed: 24464019) »
  • Horn S  et al. Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. Endocrinology 154:968-79 (2013). Read more (PubMed: 23307789) »
  • Zhang B  et al. Thyroid hormone analogue stimulates keratinocyte proliferation but inhibits cell differentiation in epidermis. Int J Immunopathol Pharmacol 25:859-69 (0). Read more (PubMed: 23298477) »

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