Tiron, superoxide scavenger and antioxidant (ab146234)

Overview

  • Product name

    Tiron, superoxide scavenger and antioxidant
  • Description

    Cell permeable superoxide scavenger and antioxidant.
  • Alternative names

    • 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt
    • Disodium-1,2-dihydroxybenzene-3,5-disulfonate
    • Pyrocatechol-3,5-disulfonic acid disodium salt
    • Sodium catechol sulfate
    • Tiferron
    see all
  • Biological description

    Cell permeable superoxide scavenger and antioxidant. Also used as indicator for complexometry. Can form complexes with titanium and iron.

  • CAS Number

    149-45-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt
  • Molecular weight

    314.20
  • Molecular formula

    C6H4Na2O8S2
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Marcén M  et al. Oxidative stress in E. coli cells upon exposure to heat treatments. Int J Food Microbiol 241:198-205 (2017). Read more (PubMed: 27794248) »
  • Kim JS  et al. Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 223:36-45 (2006). Read more (PubMed: 16635542) »
  • Watkins MT  et al. Synthesis of 8-epi-prostaglandin F2alpha by human endothelial cells: role of prostaglandin H2 synthase. Biochem J 344 Pt 3:747-54 (1999). Read more (PubMed: 10585861) »
  • Netto LE  et al. Iron(III) binding in DNA solutions: complex formation and catalytic activity in the oxidation of hydrazine derivatives. Chem Biol Interact 79:1-14 (1991). Read more (PubMed: 1647885) »
  • Ledenev AN  et al. A simple assay of the superoxide generation rate with Tiron as an EPR-visible radical scavenger. Biochem Int 13:391-6 (1986). Read more (PubMed: 3021163) »

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