Overview

  • Product name

    Anti-Tissue kallikrein antibody
    See all Tissue kallikrein primary antibodies
  • Description

    Rabbit polyclonal to Tissue kallikrein
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide within Human Tissue kallikrein aa 122-180 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P06870

  • Positive control

    • Rat kidney tissue; Human breast carcinoma tissue.
  • General notes

    Protein previously labeled as Kallikrein 1.

Properties

Applications

Our Abpromise guarantee covers the use of ab217203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
  • Tissue specificity

    Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
  • Sequence similarities

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications

    The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.
  • Information by UniProt
  • Database links

  • Alternative names

    • Glandular kallikrein 1 antibody
    • hK 1 antibody
    • hK1 antibody
    • Kallikrein serine protease 1 antibody
    • Kallikrein-1 antibody
    • Kidney/pancreas/salivary gland kallikrein antibody
    • Klk 6 antibody
    • KLK1 antibody
    • KLK1_HUMAN antibody
    • Klk6 antibody
    • KLKR antibody
    • Tissue kallikrein antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Rat kidney tissue labeling Tissue kallikrein with ab217203 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human breast carcinoma tissue labeling Tissue kallikrein with ab217203 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

References

ab217203 has not yet been referenced specifically in any publications.

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