Product nameTivozanib, VEGF receptor tyrosine kinase inhibitor
DescriptionPotent VEGF receptor tyrosine kinase inhibitor
Potent VEGF receptor tyrosine kinase inhibitor. Inhibits all three VEGF receptors (IC50 vlaues are 30, 6.5, and 15 nM for VEGFR-1, VEGFR-2 and VEGFR-3 respectively in a cell-free kinase assay). Also inhibits PDGFR and c-Kit. Has antitumor, antiangiogenesis and antigrowth properties.
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Soluble in DMSO to 40 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Guo S et al. Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties. Bioorg Med Chem Lett 25:2425-8 (2015). Read more (PubMed: 25908516) »
- Jamil MO et al. Tivozanib: status of development. Curr Oncol Rep 17:24 (2015). Read more (PubMed: 25895472) »
- Nakamura K et al. KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res 66:9134-42 (2006). Read more (PubMed: 16982756) »