Product nameTKD Peptide (Hsp70 Peptide), Natural killer (NK) cell activator
DescriptionHsp70 Peptide. Natural killer (NK) cell activator
- Hsp70 Peptide
Hsp70 Peptide. Natural killer (NK) cell activator. TKD peptide is a partial hsp70 sequence (TKDNNLLGRFELSG - aa. 450-463) and has identical effects on NK cells as full-length Hsp70 protein, being able to stimulate the cytolytic and proliferative activity of NK cells at equivalent concentrations to full-length Hsp70 protein. Incubation of peripheral blood lymphocyte cells with TKD peptide plus low-dose interleukin 2 (IL-2) enhances the cytolytic activity of NK cells against Hsp70 membrane-positive tumors, in vitro and in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Hromadnikova I et al. Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells. PLoS One 11:e0151535 (2016). Read more (PubMed: 26982331) »
- Hromadnikova I et al. Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp-70-derived 14-mer peptide (TKD) on the expression of NK cell activatory and inhibitory receptors. Mediators Inflamm 2013:405295 (2013). Read more (PubMed: 23476104) »
- Krause SW et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial. Clin Cancer Res 10:3699-707 (2004). Read more (PubMed: 15173076) »
- Multhoff G et al. A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity. Cell Stress Chaperones 6:337-44 (2001). Read more (PubMed: 11795470) »