TLCK (Tosyl-L-lysyl-chloromethane hydrochloride), Trypsin inhibitor (ab144542)

Overview

  • Product name

    TLCK (Tosyl-L-lysyl-chloromethane hydrochloride), Trypsin inhibitor
  • Description

    Irreversible inhibitor of trypsin and trypsin-like serine proteases
  • Alternative names

    • Tosyl-L-lysyl-chloromethane hydrochloride
  • Biological description

    Irreversible inhibitor of trypsin and trypsin-like serine proteases. Blocks LPS- or cytokine-induced NF-κB activation. Inhibits caspase processing; blocks apoptosis. Active in vitro and in vivo.
  • Purity

    > 95%
  • General notes

    This product has been reported to be very unstable in solutions with a pH above 6, at 25 oC.

  • CAS Number

    4238-41-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Stöppler H  et al. The serine protease inhibitors TLCK and TPCK inhibit the in vitro immortalization of primary human keratinocytes by HPV-18 DNA. Oncogene 13:1545-8 (1996). Read more (PubMed: 8875993) »
  • Mackman N Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. J Biol Chem 269:26363-7 (1994). Read more (PubMed: 7929355) »
  • Tudela J  et al. Irreversible inhibition of trypsin by TLCK. A continuous method for kinetic study of irreversible enzymatic inhibitors in the presence of substrate. Int J Biochem 18:285-8 (1986). Read more (PubMed: 3956844) »

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