Overview

  • Product name

    Anti-TLK1 (phospho S743) antibody
    See all TLK1 primary antibodies
  • Description

    Rabbit polyclonal to TLK1 (phospho S743)
  • Host species

    Rabbit
  • Specificity

    ab191509 detects endogenous levels of TLK1 protein only when phosphorylated at Ser743.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human TLK1 (phospho S743).
    Database link: Q9UKI8

  • Positive control

    • MCF-7 and H9C2 whole cell lysates; Rat brain tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab191509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 87 kDa.

Target

  • Function

    Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
  • Tissue specificity

    Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • PKU beta antibody
    • PKU-beta antibody
    • serine threonine protein kinase antibody
    • Serine/threonine protein kinase tousled like 1 antibody
    • Serine/threonine-protein kinase tousled-like 1 antibody
    • SNARE protein kinase SNAK antibody
    • Tlk1 antibody
    • TLK1_HUMAN antibody
    • Tousled like kinase 1 antibody
    • Tousled-like kinase 1 antibody
    see all

Images

  • All lanes : Anti-TLK1 (phospho S743) antibody (ab191509)

    Lane 1 : MCF-7 whole cell lysate
    Lane 2 : Rat brain tissue lysate
    Lane 3 : H9C2 whole cell lysate

    Predicted band size: 87 kDa

References

ab191509 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191509.
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