Overview

  • Product name

  • Description

    Rabbit polyclonal to TLL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human TLL1 aa 30-57.
    Sequence:

    GLDYDYTFDGNEEDKTETIDYKDPCKAA


    Database link: O43897

  • Positive control

    • HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab220904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
  • Involvement in disease

    Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:613087]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
  • Sequence similarities

    Belongs to the peptidase M12A family.
    Contains 5 CUB domains.
    Contains 2 EGF-like domains.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ASD6 antibody
    • TLL antibody
    • TLL1 antibody
    • TLL1_HUMAN antibody
    • Tolloid like 1 antibody
    • Tolloid-like protein 1 antibody
    see all

Images

  • Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized HeLa cells labeling TLL1 with ab220904 at 4 µg/ml (green).

References

ab220904 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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