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    tlr10-antibody-ab21273.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Anti-TLR10 antibody (ab21273)

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Western blot - Anti-TLR10 antibody (ab21273)

    Key features and details

    • Rabbit polyclonal to TLR10
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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    Overview

    • Product name

      Anti-TLR10 antibody
      See all TLR10 primary antibodies
    • Description

      Rabbit polyclonal to TLR10
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Synthetic peptide corresponding to 14 amino acids near the middle of TLR10 (Human).

    • Positive control

      • Human lymph node cell lysate.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C.
    • Storage buffer

      pH: 7.2
      Preservative: 0.02% Sodium azide
      Constituent: PBS
    • Concentration information loading...
    • Purification notes

      Ion exchange chromatography.
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Immunology
      • Immunoglobulins
      • Receptors
      • Immunology
      • Innate Immunity
      • TLR Signaling

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Immunizing Peptide (Blocking)

      • Active human TLR10 peptide (ab39866)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab21273 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 94 kDa.Can be blocked with Active human TLR10 peptide (ab39866).
    Notes
    WB
    Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 94 kDa.Can be blocked with Active human TLR10 peptide (ab39866).

    Target

    • Function

      Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    • Tissue specificity

      Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
    • Sequence similarities

      Belongs to the Toll-like receptor family.
      Contains 15 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 TIR domain.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q9BXR5 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 81793 Human
      • Omim: 606270 Human
      • SwissProt: Q9BXR5 Human
      • Unigene: 120551 Human
      • Alternative names

        • CD 290 antibody
        • CD 290 antigen antibody
        • CD290 antibody
        • CD290 antigen antibody
        • MGC104967 antibody
        • MGC126398 antibody
        • MGC126399 antibody
        • OTTHUMP00000158729 antibody
        • OTTHUMP00000218162 antibody
        • TLR10 antibody
        • TLR10_HUMAN antibody
        • Toll like receptor 10 antibody
        • Toll-like receptor 10 antibody
        • UNQ315/PRO358 antibody
        see all

      Images

      • Western blot - Anti-TLR10 antibody (ab21273)
        Western blot - Anti-TLR10 antibody (ab21273)
        Lane 1 : Anti-TLR10 antibody (ab21273) at 0.5 µg/ml
        Lane 2 : Anti-TLR10 antibody (ab21273) at 1 µg/ml

        All lanes : Human lymph node cell lysates

        Predicted band size: 94 kDa
        Observed band size: 75 kDa why is the actual band size different from the predicted?

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab21273? Please let us know so that we can cite the reference in this datasheet.

      ab21273 has not yet been referenced specifically in any publications.

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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