Key features and details
- Mouse monoclonal [TL2.1] to TLR2 (PE)
- Suitable for: IHC-P, Functional Studies, IHC-Fr, WB, IP, ICC/IF, Flow Cyt
- Reacts with: Dog, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
Product nameAnti-TLR2 antibody [TL2.1] (PE)
See all TLR2 primary antibodies
DescriptionMouse monoclonal [TL2.1] to TLR2 (PE)
ConjugationPE. Ex: 488nm, Em: 575nm
Tested applicationsSuitable for: IHC-P, Functional Studies, IHC-Fr, WB, IP, ICC/IF, Flow Cytmore details
Species reactivityReacts with: Dog, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset
Recombinant full length protein corresponding to Human TLR2. Produced by the CHO/CD14 reporter cell line.
Database link: O60603
- Peripheral blood mononuclear cells, granulocytes and monocytes; Human tonsil tissue.
Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: 1% BSA, 99% PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab171568 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||Use at an assay dependent concentration.|
Fixed in acetone.
|WB||Use a concentration of 1 µg/ml. Use under non reducing condition. Predicted molecular weight: 90 kDa.|
|IP||Use at an assay dependent concentration.|
|ICC/IF||Use a concentration of 5 - 10 µg/ml.
4% paraformaldehyde fixed.
|Flow Cyt||Use at an assay dependent concentration.
2 µg antibody per 300000 cells
ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
FunctionCooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Tissue specificityHighly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Sequence similaritiesBelongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
modificationsGlycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
- Information by UniProt
- CD282 antibody
- CD282 antigen antibody
- TIL 4 antibody
ab171568 has been referenced in 1 publication.
- Hou Y et al. Up-regulation of DcR3 in microbial toxins-stimulated HUVECs involves NF-?B signalling. BMC Biochem 19:13 (2018). PubMed: 30587127