Overview

  • Product name

    Anti-TLR2 antibody [TL2.1] (Phycoerythrin)
    See all TLR2 primary antibodies
  • Description

    Mouse monoclonal [TL2.1] to TLR2 (Phycoerythrin)
  • Host species

    Mouse
  • Conjugation

    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications

    Suitable for: IHC-P, Functional Studies, IHC-Fr, WB, IP, ICC/IF, Flow Cytmore details
  • Species reactivity

    Reacts with: Dog, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset
  • Immunogen

    Recombinant full length protein corresponding to Human TLR2. Produced by the CHO/CD14 reporter cell line.
    Database link: O60603

  • Positive control

    • Peripheral blood mononuclear cells, granulocytes and monocytes; Human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab171568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50.
Functional Studies Use at an assay dependent concentration.
IHC-Fr 1/50.

Fixed in acetone.

WB Use a concentration of 1 µg/ml. Use under non reducing condition. Predicted molecular weight: 90 kDa.
IP Use at an assay dependent concentration.
ICC/IF Use a concentration of 5 - 10 µg/ml.

4% paraformaldehyde fixed.

Flow Cyt Use at an assay dependent concentration.

2 µg antibody per 300000 cells

 

 

 

 

ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • Tissue specificity

    Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • Sequence similarities

    Belongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Post-translational
    modifications

    Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

References

This product has been referenced in:

See 1 Publication for this product

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