TLR2-IN-C29 (ab285439)
Key features and details
TLR2/1 and TLR2/6 signaling inhibitor
- CAS Number: 363600-92-4
- Purity: >= 98%
Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TLR2-IN-C29 -
Description
TLR2/1 and TLR2/6 signaling inhibitor
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Alternative names
- TLR2 inhibitor C29
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Biological description
Inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. It prevents the early activation of TLR2-mediated signaling, including NF-κB and MAPKs, as well as MyD88 recruitment to TLR2 in THP-1 cells.
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Purity
>= 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called B2121 TLR2-IN-C29. B2121-5 is the same size as the 5 mg size of ab285439.
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CAS Number
363600-92-4
Properties
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Chemical name
3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid
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Molecular weight
285.29 -
Molecular formula
C16H15NO4 -
PubChem identifier
3579893 -
Storage instructions
Shipped at 4°C. Store at -20°C. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO
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SMILES
CC1=C(C=CC=C1NC=C2C=CC=C(C2=O)OC)C(=O)O -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab285439 has not yet been referenced specifically in any publications.
