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    tlr4md2-antibody-mts510-low-endotoxin-azide-free-ab174606.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free (ab174606)

  • Datasheet
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Key features and details

  • Rat monoclonal [MTS510] to TLR4/MD2 - Low endotoxin, Azide free
  • Reacts with: Mouse
  • Isotype: IgG2a

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Conjugation
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Overview

  • Product name

    Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free
  • Description

    Rat monoclonal [MTS510] to TLR4/MD2 - Low endotoxin, Azide free
  • Host species

    Rat
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control

    • PECs
  • General notes

    Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by the LAL assay.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Constituent: PBS

    Aqueous buffer.
  • Carrier free

    Yes
  • Concentration information loading...
  • Clonality

    Monoclonal
  • Clone number

    MTS510
  • Isotype

    IgG2a
  • Light chain type

    kappa
  • Research areas

    • Immunology
    • Innate Immunity
    • Macrophage / Inflamm.
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • NFkB Pathway

Associated products

  • Compatible Secondaries

    • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
    • Goat Anti-Rat IgG H&L (HRP) (ab205720)
  • Isotype control

    • Rat IgG2a, kappa monoclonal [RTK2758] - Isotype Control (ab18450)

Target

  • Relevance

    Toll like receptor 4 (TLR4) is a member of the Toll like receptors (TLRs) family comprising a group of evolutionary conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands. All members of the family share a sequence in their cytoplasmic domain with the Type I IL1 receptor (TIR) and this highly conserved motif is involved in bimolecular interactions necessary for signal transduction. Cooperates with MD2 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni2+. These responses require non-conserved histidines and are, therefore, species-specific.
  • Cellular localization

    Type I membrane protein.
  • Database links

    • Entrez Gene: 17087 Mouse
    • Entrez Gene: 21898 Mouse
    • SwissProt: Q9JHF9 Mouse
    • SwissProt: Q9QUK6 Mouse
    • Unigene: 116844 Mouse
    • Unigene: 38049 Mouse
    • Form

      There are 3 TLR4 isoforms produced by alternative splicing.
    • Alternative names

      • ARMD10 antibody
      • CD284 antibody
      • CD284 antigen antibody
      • ESOP 1 antibody
      • Homolog of Drosophila toll antibody
      • hToll antibody
      • LY96 antibody
      • Lymphocyte antigen 96 antibody
      • MD2 protein antibody
      • myeloid differentiation protein 2 antibody
      • protein MD 2 antibody
      • TOLL antibody
      • Toll endotoxin hyporesponsiveness antibody
      • Toll like receptor 4 antibody
      see all

    Protocols

    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab174606? Please let us know so that we can cite the reference in this datasheet.

    ab174606 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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