Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free (ab174606)

Overview

  • Product name
    Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free
  • Description
    Rat monoclonal [MTS510] to TLR4/MD2 - Low endotoxin, Azide free
  • Host species
    Rat
  • Tested applications
    Suitable for: Flow Cyt, Functional Studiesmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control
    • PECs
  • General notes

    Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by the LAL assay.

Properties

Applications

Our Abpromise guarantee covers the use of ab174606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 105-8 cells.

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

Functional Studies Use at an assay dependent concentration.

Target

  • Relevance
    Toll like receptor 4 (TLR4) is a member of the Toll like receptors (TLRs) family comprising a group of evolutionary conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands. All members of the family share a sequence in their cytoplasmic domain with the Type I IL1 receptor (TIR) and this highly conserved motif is involved in bimolecular interactions necessary for signal transduction. Cooperates with MD2 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni2+. These responses require non-conserved histidines and are, therefore, species-specific.
  • Cellular localization
    Type I membrane protein.
  • Database links
  • Form
    There are 3 TLR4 isoforms produced by alternative splicing.
  • Alternative names
    • ARMD10 antibody
    • CD284 antibody
    • CD284 antigen antibody
    • ESOP 1 antibody
    • Homolog of Drosophila toll antibody
    • hToll antibody
    • LY96 antibody
    • Lymphocyte antigen 96 antibody
    • MD2 protein antibody
    • myeloid differentiation protein 2 antibody
    • protein MD 2 antibody
    • TOLL antibody
    • Toll endotoxin hyporesponsiveness antibody
    • Toll like receptor 4 antibody
    see all

References

ab174606 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab174606.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up