Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free (ab174606)
Key features and details
- Rat monoclonal [MTS510] to TLR4/MD2 - Low endotoxin, Azide free
- Reacts with: Mouse
- Isotype: IgG2a
Overview
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Product name
Anti-TLR4/MD2 antibody [MTS510] - Low endotoxin, Azide free -
Description
Rat monoclonal [MTS510] to TLR4/MD2 - Low endotoxin, Azide free -
Host species
Rat -
Species reactivity
Reacts with: Mouse -
Immunogen
The details of the immunogen for this antibody are not available.
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Positive control
- PECs
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General notes
Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by the LAL assay.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Constituent: PBS
Aqueous buffer. -
Carrier free
Yes -
Concentration information loading... -
Clonality
Monoclonal -
Clone number
MTS510 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Relevance
Toll like receptor 4 (TLR4) is a member of the Toll like receptors (TLRs) family comprising a group of evolutionary conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands. All members of the family share a sequence in their cytoplasmic domain with the Type I IL1 receptor (TIR) and this highly conserved motif is involved in bimolecular interactions necessary for signal transduction. Cooperates with MD2 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni2+. These responses require non-conserved histidines and are, therefore, species-specific. -
Cellular localization
Type I membrane protein. -
Database links
- Entrez Gene: 17087 Mouse
- Entrez Gene: 21898 Mouse
- SwissProt: Q9JHF9 Mouse
- SwissProt: Q9QUK6 Mouse
- Unigene: 116844 Mouse
- Unigene: 38049 Mouse
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Form
There are 3 TLR4 isoforms produced by alternative splicing. -
Alternative names
- ARMD10 antibody
- CD284 antibody
- CD284 antigen antibody
see all
Datasheets and documents
References (0)
ab174606 has not yet been referenced specifically in any publications.
