Overview

  • Product name
    Anti-TLR5 antibody [EPR10373]
    See all TLR5 primary antibodies
  • Description
    Rabbit monoclonal [EPR10373] to TLR5
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human TLR5.

  • Positive control
    • HT29, A549, THP1 and HeLa cell lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab168382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 97 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    • Tissue specificity
      Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
    • Involvement in disease
      Systemic lupus erythematosus 1
    • Sequence similarities
      Belongs to the Toll-like receptor family.
      Contains 22 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 TIR domain.
    • Post-translational
      modifications
      Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
      Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ10052 antibody
      • MGC126430 antibody
      • MGC126431 antibody
      • SLEB1 antibody
      • TIL 3 antibody
      • TIL3 antibody
      • TLR 5 antibody
      • Tlr5 antibody
      • TLR5_HUMAN antibody
      • Toll like receptor 5 antibody
      • Toll like receptor 5 precursor antibody
      • Toll-like receptor 5 antibody
      • Toll/interleukin 1 receptor like protein 3 antibody
      • Toll/interleukin-1 receptor-like protein 3 antibody
      see all

    Images

    • All lanes : Anti-TLR5 antibody [EPR10373] (ab168382) at 1/1000 dilution

      Lane 1 : HT29 cell lysate
      Lane 2 : A549 cell lysate
      Lane 3 : THP1 cell lysate
      Lane 4 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 97 kDa

    References

    This product has been referenced in:
    • Karlsen M  et al. Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögren's Syndrome. Scand J Immunol 85:220-226 (2017). Read more (PubMed: 27943374) »

    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab168382.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up