Overview

  • Product name
    Anti-TLR6 antibody [TLR6.127] (Phycoerythrin)
    See all TLR6 primary antibodies
  • Description
    Mouse monoclonal [TLR6.127] to TLR6 (Phycoerythrin)
  • Host species
    Mouse
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications
    Suitable for: Flow Cyt, IP, ICC/IF, Functional Studiesmore details
  • Species reactivity
    Reacts with: Human

Properties

Applications

Our Abpromise guarantee covers the use of ab171564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50.

ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

IP 1/50.
ICC/IF 1/50.
Functional Studies Use at an assay dependent concentration.

For neutralization of biological activity, in vitro dilutions have to be made according to the amounts of TLR6 to be inactivated.

Target

  • Function
    Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
  • Tissue specificity
    Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
  • Sequence similarities
    Belongs to the Toll-like receptor family.
    Contains 12 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • Cellular localization
    Cell membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD286 antibody
    • CD286 antigen antibody
    • TLR 6 antibody
    • Tlr6 antibody
    • TLR6_HUMAN antibody
    • Toll like receptor 6 precursor antibody
    • Toll-like receptor 6 antibody
    see all

References

ab171564 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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