Anti-TMEM16A antibody - C-terminal (ab191040)
Key features and details
- Rabbit polyclonal to TMEM16A - C-terminal
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
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Product name
Anti-TMEM16A antibody - C-terminal
See all TMEM16A primary antibodies -
Description
Rabbit polyclonal to TMEM16A - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat
Predicted to work with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human TMEM16A aa 900 to the C-terminus (C terminal).
Database link: Q5XXA6 -
Positive control
- Rat liver and Rat skeletal muscle tissue lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate, 2% Trehalose -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191040 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 0.5 µg/ml. Detects a band of approximately 114 kDa (predicted molecular weight: 114 kDa).
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Notes |
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WB
Use a concentration of 0.5 µg/ml. Detects a band of approximately 114 kDa (predicted molecular weight: 114 kDa). |
Target
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Function
Acts as a calcium-activated chloride channel. Required for normal tracheal development. -
Tissue specificity
Broadly expressed with higher levels in liver and skeletal muscle. -
Sequence similarities
Belongs to the anoctamin family. -
Domain
The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region. -
Cellular localization
Cell membrane. Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 55107 Human
- Entrez Gene: 101772 Mouse
- Entrez Gene: 309135 Rat
- Omim: 610108 Human
- SwissProt: Q5XXA6 Human
- SwissProt: Q8BHY3 Mouse
- Unigene: 503074 Human
- Unigene: 26700 Mouse
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Alternative names
- ANO 1 antibody
- ANO1 antibody
- ANO1_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab191040 has been referenced in 2 publications.
- Kondo R et al. Downregulation of Ca2+-Activated Cl- Channel TMEM16A Mediated by Angiotensin II in Cirrhotic Portal Hypertensive Mice. Front Pharmacol 13:831311 (2022). PubMed: 35370660
- Wang Q et al. Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells. J Neurogastroenterol Motil 25:589-601 (2019). PubMed: 31587550