• Product name
  • Description
    Rabbit polyclonal to TMEM43
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 194-223 of Human TMEM43 (NP_077310.1).

  • Positive control
    • MDA-MB231 cell line lysate.



Our Abpromise guarantee covers the use of ab113116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.


  • Function
    May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.
  • Tissue specificity
    Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.
  • Involvement in disease
    Defects in TMEM43 are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5) [MIM:604400]; also known as arrhythmogenic right ventricular cardiomyopathy (ARVC5). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • Sequence similarities
    Belongs to the TMEM43 family.
  • Cellular localization
    Endoplasmic reticulum. Nucleus inner membrane. Retained in the inner nuclear membrane through interaction with EMD and A-and B-lamins. The N- and C-termini are orientated towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARVC5 antibody
    • ARVD5 antibody
    • EDMD7 antibody
    • LUMA antibody
    • Protein LUMA antibody
    • Tmem43 antibody
    • TMM43_HUMAN antibody
    • Transmembrane protein 43 antibody
    see all


  • Anti-TMEM43 antibody (ab113116) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size: 45 kDa


This product has been referenced in:
  • Dionisio-Vicuña MN  et al. VPS28, an ESCRT-I protein, regulates mitotic spindle organization via Gß?, EG5 and TPX2. Biochim Biophys Acta 1865:1012-1022 (2018). Human . Read more (PubMed: 29548937) »
  • Guixà-González R  et al. Membrane cholesterol access into a G-protein-coupled receptor. Nat Commun 8:14505 (2017). Read more (PubMed: 28220900) »

See all 2 Publications for this product

Customer reviews and Q&As

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Please note you do not need the above code to place the initial order for ab113116. You only need it to redeem your free primary antibody after you have submitted your Abreview relating your experience testing ab113116 with mouse samples.
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