Overview

  • Product name

  • Description

    Mouse polyclonal to TMEM49/VMP1
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human TMEM49/VMP1.

  • Positive control

    • TMEM49/VMP1 transfected 293T lysate.
  • General notes

     This product was previously labelled as TMEM49

     

Properties

Applications

Our Abpromise guarantee covers the use of ab69224 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 47 kDa (predicted molecular weight: 47 kDa).

Target

  • Function

    Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
  • Sequence similarities

    Belongs to the VMP1 family.
  • Cellular localization

    Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane. Vacuole membrane. Endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZP566I133 antibody
    • ectopic P-granules autophagy protein 3 homolog antibody
    • NF E2 induceble protein 2 antibody
    • NF E2 inducible protein 2 antibody
    • ni 2 antibody
    • protein ni 2 antibody
    • Tango5 antibody
    • TDC1 antibody
    • TMEM49 antibody
    • Transmembrane protein 49 antibody
    • transport and golgi organization 5 homolog antibody
    • Vacuole membrane protein 1 antibody
    • vmp1 antibody
    • VMP1_HUMAN antibody
    see all

Images

  • All lanes : Anti-TMEM49/VMP1 antibody (ab69224) at 1/500 dilution

    Lane 1 : TMEM49/VMP1 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Lane 1 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
    Lane 2 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size: 47 kDa
    Observed band size: 47 kDa

References

This product has been referenced in:

  • Qu A  et al. Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. PLoS One 9:e90952 (2014). WB ; Human . Read more (PubMed: 24632577) »
  • Lo Ré AE  et al. Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells. J Biol Chem 287:25325-34 (2012). WB ; Human . Read more (PubMed: 22535956) »
See all 2 Publications for this product

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