Anti-TMEM70 antibody (ab106654)
Key features and details
- Rabbit polyclonal to TMEM70
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TMEM70 antibody -
Description
Rabbit polyclonal to TMEM70 -
Host species
Rabbit -
Specificity
Two isoforms of TMEM70 are known to exist; ab106654 will only recognize Isoform 1. ab106654 is predicted not to cross-react with other TMEM proteins. -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human TMEM70 (internal sequence). The immunogen is located within amino acids 150 - 200 (14 amino acid synthetic peptide) of TMEM70.
Database link: Q9BUB7 -
Positive control
- WB: Human liver tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106654 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 5 µg/ml.
Validated in rat samples only. |
|
WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 29 kDa.
Validated in human samples only. |
|
IF |
Use a concentration of 20 µg/ml.
Validated in rat samples only. |
Notes |
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IHC-P
Use a concentration of 5 µg/ml. Validated in rat samples only. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 29 kDa. Validated in human samples only. |
IF
Use a concentration of 20 µg/ml. Validated in rat samples only. |
Target
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Function
Involved in biogenesis of mitochondrial ATP synthase. -
Involvement in disease
Defects in TMEM70 are a cause of mitochondrial encephalocardiomyopathy neonatal due to ATP synthase deficiency (MT-ATPSD) [MIM:604273]; also known as ATPase deficiency. A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. -
Sequence similarities
Belongs to the TMEM70 family. -
Cellular localization
Mitochondrion inner membrane. - Information by UniProt
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Database links
- Entrez Gene: 54968 Human
- Omim: 612418 Human
- SwissProt: Q9BUB7 Human
- Unigene: 106650 Human
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Alternative names
- FLJ20533 antibody
- MC5DN2 antibody
- OTTHUMP00000226855 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab106654 has been referenced in 2 publications.
- Du L et al. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab 29:1363-1375.e8 (2019). PubMed: 30745181
- de Souza AP et al. Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach. Proteome Sci 13:32 (2015). PubMed: 26633942