Key features and details
- Rabbit polyclonal to TMEM70
- Suitable for: IHC-P, WB
- Reacts with: Rat, Human
- Isotype: IgG
Product nameAnti-TMEM70 antibody
See all TMEM70 primary antibodies
DescriptionRabbit polyclonal to TMEM70
SpecificityTwo isoforms of TMEM70 are known to exist; ab106654 will only recognize Isoform 1. ab106654 is predicted not to cross-react with other TMEM proteins.
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Rat, Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human TMEM70 (internal sequence). The immunogen is located within amino acids 150 - 200 (14 amino acid synthetic peptide) of TMEM70.
Database link: Q9BUB7
- Human liver tissue lysate; Rat liver tissue
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months).
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab106654 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 µg/ml.
Validated in rat samples only.
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 29 kDa.
Validated in human samples only.
|IF||Use a concentration of 20 µg/ml.
Validated in rat samples only.
FunctionInvolved in biogenesis of mitochondrial ATP synthase.
Involvement in diseaseDefects in TMEM70 are a cause of mitochondrial encephalocardiomyopathy neonatal due to ATP synthase deficiency (MT-ATPSD) [MIM:604273]; also known as ATPase deficiency. A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
Sequence similaritiesBelongs to the TMEM70 family.
Cellular localizationMitochondrion inner membrane.
- Information by UniProt
- FLJ20533 antibody
- MC5DN2 antibody
- OTTHUMP00000226855 antibody
ab106654 has been referenced in 2 publications.
- Du L et al. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab 29:1363-1375.e8 (2019). PubMed: 30745181
- de Souza AP et al. Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach. Proteome Sci 13:32 (2015). PubMed: 26633942