Overview

  • Product name

    TMP-153,  ACAT inhibitor
  • Description

    Potent, non-competitive ACAT inhibitor
  • Biological description

    Potent, non-competitive ACAT inhibitor (IC50 = 5-10 nM). Inhibits cholesterol esterification (IC50 values are 150 and 330 nM for L S180 and HepG2 cells respectively). Lowers plasma cholesterol levels and cholesterol absorption in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    128831-46-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[4-(2-Chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea
  • Molecular weight

    437.87
  • Molecular formula

    C24H18ClF2N3O
  • PubChem identifier

    125289
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C=C2C(=C1)C(=C(C=N2)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bate C  et al. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology 54:1247-53 (2008). Read more (PubMed: 18448139) »
  • Sugiyama Y  et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis 113:71-8 (1995). Read more (PubMed: 7755657) »
  • Sugiyama Y  et al. TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters. Atherosclerosis 118:145-53 (1995). Read more (PubMed: 8579624) »

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