- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-TN-X antibody
See all TN-X primary antibodies -
DescriptionRabbit polyclonal to TN-X
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Host speciesRabbit
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Tested applicationsSuitable for: IHC-Pmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse
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Immunogen
Synthetic peptide corresponding to Human TN-X (internal sequence).
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Positive control
- Human breast carcinoma tissue.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS, 0.88% Sodium chloride -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab111270 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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FunctionAppears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
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Tissue specificityHighly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
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Involvement in diseaseTenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Sequence similaritiesBelongs to the tenascin family.
Contains 19 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 32 fibronectin type-III domains. -
Developmental stageExpression levels are lower in adults than in children.
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Cellular localizationSecreted > extracellular space > extracellular matrix.
- Information by UniProt
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Database links
- Entrez Gene: 7148 Human
- Entrez Gene: 81877 Mouse
- Omim: 600985 Human
- SwissProt: P22105 Human
- Unigene: 485104 Human
- Unigene: 290527 Mouse
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Alternative names
- EDS3 antibody
- Ehlers Danlos like syndrome antibody
- Growth inhibiting protein 45 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody (ab111270)Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using 1/50 ab111270. The picture on the right is treated with the synthesized peptide
Protocols
References
ab111270 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
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