Product nameAnti-TN-X antibody
See all TN-X primary antibodies
DescriptionMouse polyclonal to TN-X
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human TN-X aa 1-673.
- TN-X transfected 293T cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab67586 in the following tested applications.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionAppears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
Tissue specificityHighly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
Involvement in diseaseTenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similaritiesBelongs to the tenascin family.
Contains 19 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 32 fibronectin type-III domains.
Developmental stageExpression levels are lower in adults than in children.
Cellular localizationSecreted > extracellular space > extracellular matrix.
- Information by UniProt
- EDS3 antibody
- Ehlers Danlos like syndrome antibody
- Growth inhibiting protein 45 antibody
All lanes : Anti-TN-X antibody (ab67586) at 1/500 dilution
Lane 1 : TN-X transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 464 kDa
Observed band size: 80 kDa why is the actual band size different from the predicted?
ab67586 has not yet been referenced specifically in any publications.