Recombinant Anti-TN-X antibody [SP230] (ab183346)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)](https://www.abcam.com/ps/products/183/ab183346/Images/ab183346-213746-anti-tn-x-antibody-sp230-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP230] to TN-X
- Suitable for: IHC-P
- Reacts with: Human
Overview
-
Product name
Anti-TN-X antibody [SP230]
See all TN-X primary antibodies -
Description
Rabbit monoclonal [SP230] to TN-X -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species IHC-P Human
-
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
Positive control
- Human mesothelioma tissue
-
General notes
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
Purity
Protein A/G purified -
Purification notes
Purified from TCS by protein A/G. -
Clonality
Monoclonal -
Clone number
SP230 -
Isotype
IgG -
Research areas
Associated products
-
Alternative Versions
-
Isotype control
-
Recombinant Protein
-
Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab183346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| IHC-P |
Human
|
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
| Notes |
|---|
|
IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Function
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. -
Tissue specificity
Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland. -
Involvement in disease
Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry. -
Sequence similarities
Belongs to the tenascin family.
Contains 19 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 32 fibronectin type-III domains. -
Developmental stage
Expression levels are lower in adults than in children. -
Cellular localization
Secreted > extracellular space > extracellular matrix. - Information by UniProt
-
Database links
- Entrez Gene: 7148 Human
- Omim: 600985 Human
- SwissProt: P22105 Human
- Unigene: 485104 Human
-
Alternative names
- EDS3 antibody
- Ehlers Danlos like syndrome antibody
- Growth inhibiting protein 45 antibody
see all
Images
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)
Immunohistochemical analysis of paraffin embedded Human mesothelioma tissue labeling TN-X with ab183346 at 1/100 dilution.
-
![Anti-TN-X antibody [SP230] (ab183346)](https://www.abcam.com/ps/products/183/ab183346/Images/ab183346-2-benefits-of-recombinant-antibodies.png)
Anti-TN-X antibody [SP230] (ab183346)
References (0)
ab183346 has not yet been referenced specifically in any publications.
