Recombinant Anti-TN-X antibody [SP230] (ab183346)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-TN-X antibody [SP230]
See all TN-X primary antibodies -
Description
Rabbit monoclonal [SP230] to TN-X -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human TN-X aa 1-100. The exact sequence is proprietary.
Database link: P22105 -
Positive control
- Human mesothelioma tissue
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General notes
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
Purity
Protein A/G purified -
Purification notes
Purified from TCS by protein A/G. -
Clonality
Monoclonal -
Clone number
SP230 -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
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Related Products
Applications
Our Abpromise guarantee covers the use of ab183346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. -
Tissue specificity
Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland. -
Involvement in disease
Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry. -
Sequence similarities
Belongs to the tenascin family.
Contains 19 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 32 fibronectin type-III domains. -
Developmental stage
Expression levels are lower in adults than in children. -
Cellular localization
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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Database links
- Entrez Gene: 7148 Human
- Omim: 600985 Human
- SwissProt: P22105 Human
- Unigene: 485104 Human
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Alternative names
- EDS3 antibody
- Ehlers Danlos like syndrome antibody
- Growth inhibiting protein 45 antibody
see all
Images
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)](https://www.abcam.com/ps/products/183/ab183346/Images/ab183346-213746-anti-tn-x-antibody-sp230-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)Immunohistochemical analysis of paraffin embedded Human mesothelioma tissue labeling TN-X with ab183346 at 1/100 dilution.
Protocols
References
ab183346 has not yet been referenced specifically in any publications.
