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Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Tenascin
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RecombinantRabMAb

Recombinant Anti-TN-X antibody [SP230] (ab183346)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)
  • Anti-TN-X antibody [SP230] (ab183346)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [SP230] to TN-X
  • Suitable for: IHC-P
  • Reacts with: Human

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Overview

  • Product name

    Anti-TN-X antibody [SP230]
    See all TN-X primary antibodies
  • Description

    Rabbit monoclonal [SP230] to TN-X
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • Human mesothelioma tissue
  • General notes

    This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.60
    Preservative: 0.1% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Purification notes

    Purified from TCS by protein A/G.
  • Clonality

    Monoclonal
  • Clone number

    SP230
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • ECM Proteins
    • Tenascin

Associated products

  • Alternative Versions

    • Anti-TN-X antibody [SP230] - BSA and Azide free (ab271942)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Recombinant Protein

    • Recombinant Human TN-X protein (ab159733)
  • Related Products

    • Recombinant Human TN-X protein (ab159733)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab183346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
Application Abreviews Notes
IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
  • Tissue specificity

    Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
  • Involvement in disease

    Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the tenascin family.
    Contains 19 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 32 fibronectin type-III domains.
  • Developmental stage

    Expression levels are lower in adults than in children.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Target information above from: UniProt accession P22105 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 7148 Human
    • Omim: 600985 Human
    • SwissProt: P22105 Human
    • Unigene: 485104 Human
    • Alternative names

      • EDS3 antibody
      • Ehlers Danlos like syndrome antibody
      • Growth inhibiting protein 45 antibody
      • Hexabrachion like protein antibody
      • Hexabrachion-like protein antibody
      • HXBL antibody
      • NXB2 antibody
      • Tenascin X antibody
      • Tenascin X precursor antibody
      • Tenascin XB antibody
      • Tenascin XB1 antibody
      • Tenascin XB2 antibody
      • Tenascin-X antibody
      • TENX antibody
      • TENX_HUMAN antibody
      • TN X antibody
      • TN-X antibody
      • TNX antibody
      • TNXB antibody
      • TNXB1 antibody
      • TNXB2 antibody
      • TNXBS antibody
      • VUR8 antibody
      • XB antibody
      • XBS antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TN-X antibody [SP230] (ab183346)

      Immunohistochemical analysis of paraffin embedded Human mesothelioma tissue labeling TN-X with ab183346 at 1/100 dilution.

    • Anti-TN-X antibody [SP230] (ab183346)
      Anti-TN-X antibody [SP230] (ab183346)

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab183346? Please let us know so that we can cite the reference in this datasheet.

    ab183346 has not yet been referenced specifically in any publications.

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