Anti-TNF Receptor I antibody [55R-170] (ab106099)
Key features and details
- Armenian Hamster monoclonal [55R-170] to TNF Receptor I
- Reacts with: Mouse
- Isotype: IgG1
Overview
-
Product name
Anti-TNF Receptor I antibody [55R-170]
See all TNF Receptor I primary antibodies -
Description
Armenian Hamster monoclonal [55R-170] to TNF Receptor I -
Host species
Armenian hamster -
Species reactivity
Reacts with: Mouse -
Immunogen
Purified extracellular domain of Mouse Soluble TNF Receptor I.
-
General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituents: 0.1% BSA, PBS -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
ab106099 is 0.2 µm filtered. -
Clonality
Monoclonal -
Clone number
55R-170 -
Isotype
IgG1 -
Research areas
Associated products
-
Alternative Versions
-
Recombinant Protein
Target
-
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
Involvement in disease
Familial hibernian fever
Multiple sclerosis 5 -
Sequence similarities
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
Domain
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
Post-translational
modificationsThe soluble form is produced from the membrane form by proteolytic processing. -
Cellular localization
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
-
Database links
- Entrez Gene: 21937 Mouse
- SwissProt: P25118 Mouse
-
Alternative names
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
Protocols
Datasheets and documents
References (1)
ab106099 has been referenced in 1 publication.
- Sheehan KC et al. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181:607-17 (1995). PubMed: 7836916
