Anti-TNF Receptor I antibody [55R-170] (ab106099)
- Datasheet
- References (1)
- Protocols
Overview
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Product nameAnti-TNF Receptor I antibody [55R-170]
See all TNF Receptor I primary antibodies -
DescriptionArmenian Hamster monoclonal [55R-170] to TNF Receptor I
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Host speciesArmenian hamster
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Tested applicationsSuitable for: IP, ELISA, Functional Studies, Flow Cytmore details
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Species reactivityReacts with: Mouse
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Immunogen
Purified extracellular domain of Mouse Soluble TNF Receptor I.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Storage bufferConstituents: 0.1% BSA, PBS
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Concentration information loading... -
PurityProtein G purified
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Purification notesab106099 is 0.2 µm filtered.
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ClonalityMonoclonal
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Clone number55R-170
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IsotypeIgG1
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Research areas
Associated products
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Alternative Versions
Applications
Our Abpromise guarantee covers the use of ab106099 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IP | 1/50. | |
| ELISA | 1/50. | |
| Functional Studies | Use at an assay dependent dilution. | |
| Flow Cyt | 1/50. |
Target
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FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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Involvement in diseaseFamilial hibernian fever
Multiple sclerosis 5 -
Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats. -
DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
Post-translational
modificationsThe soluble form is produced from the membrane form by proteolytic processing. -
Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
- Information by UniProt
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Database links
- Entrez Gene: 21937 Mouse
- SwissProt: P25118 Mouse
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Alternative names
- CD120a antibody
- FPF antibody
- MGC19588 antibody
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Datasheets and documents
References
This product has been referenced in:
- Sheehan KC et al. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181:607-17 (1995). Read more (PubMed: 7836916) »
