Anti-TNF Receptor I antibody [55R-170] (ab106099)

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Overview

  • Product name

    Anti-TNF Receptor I antibody [55R-170]
    See all TNF Receptor I primary antibodies

  • Description

    Armenian Hamster monoclonal [55R-170] to TNF Receptor I

  • Host species

    Armenian hamster

  • Tested applications

    Suitable for: IP, ELISA, Functional Studies, Flow Cytmore details

  • Species reactivity

    Reacts with: Mouse

  • Immunogen

    Purified extracellular domain of Mouse Soluble TNF Receptor I.

Properties

Applications

Our Abpromise guarantee covers the use of ab106099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/50.
ELISA 1/50.
Functional Studies Use at an assay dependent dilution.
Flow Cyt 1/50.

Target

  • Function

    Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

  • Involvement in disease

    Familial hibernian fever
    Multiple sclerosis 5

  • Sequence similarities

    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.

  • Domain

    The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.

  • Post-translational
    modifications

    The soluble form is produced from the membrane form by proteolytic processing.

  • Cellular localization

    Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD120a antibody
      • FPF antibody
      • MGC19588 antibody
      • p55 antibody
      • p55-R antibody
      • p60 antibody
      • TBP1 antibody
      • TBPI antibody
      • TNF R antibody
      • TNF R55 antibody
      • TNF-R1 antibody
      • TNF-RI antibody
      • TNFAR antibody
      • TNFR-I antibody
      • TNFR1 antibody
      • TNFR55 antibody
      • TNFR60 antibody
      • TNFRI antibody
      • TNFRSF1a antibody
      • TNR1A_HUMAN antibody
      • Tumor necrosis factor receptor 1 antibody
      • Tumor necrosis factor receptor superfamily, member 1A antibody
      • Tumor necrosis factor receptor type 1 antibody
      • Tumor necrosis factor receptor type I antibody
      • Tumor necrosis factor-binding protein 1 antibody
      see all

    References

    This product has been referenced in:

    • Sheehan KC  et al. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181:607-17 (1995). Read more (PubMed: 7836916) »
    See 1 Publication for this product

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