• Product name

    Anti-TNF Receptor II antibody [HM102]
    See all TNF Receptor II primary antibodies
  • Description

    Rat monoclonal [HM102] to TNF Receptor II
  • Host species

  • Specificity

    Mouse TNF-R II and the soluble receptor.
  • Tested applications

    Suitable for: IP, IHC-Fr, Flow Cytmore details
  • Species reactivity

    Reacts with: Mouse
  • Epitope

    Extra-cellular part of the receptor.



Our Abpromise guarantee covers the use of ab7369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    The antibody is an agonistic antibody useful for cell culture experiments and for detection of TNF-R II by FACS analysis.
    Furthermore it can be used for immunoprecipitation and histology on frozen sections.
    The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-?.
  • Target

    • Function

      Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    • Sequence similarities

      Contains 4 TNFR-Cys repeats.
    • Post-translational

      Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
      A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
    • Cellular localization

      Secreted and Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • CD120b antibody
      • p75 antibody
      • p75 TNF receptor antibody
      • p75TNFR antibody
      • p80 TNF alpha receptor antibody
      • p80 TNF-alpha receptor antibody
      • Soluble TNFR1B variant 1 antibody
      • TBP-2 antibody
      • TBPII antibody
      • TNF R II antibody
      • TNF R2 antibody
      • TNF R75 antibody
      • TNF-R2 antibody
      • TNF-RII antibody
      • TNFBR antibody
      • TNFR-II antibody
      • TNFR1B antibody
      • TNFR2 antibody
      • TNFR80 antibody
      • TNFRII antibody
      • Tnfrsf1b antibody
      • TNR1B_HUMAN antibody
      • Tumor necrosis factor beta receptor antibody
      • Tumor necrosis factor binding protein 2 antibody
      • Tumor necrosis factor receptor 2 antibody
      • Tumor necrosis factor receptor superfamily member 1B antibody
      • Tumor necrosis factor receptor type II antibody
      • Tumor necrosis factor-binding protein 2 antibody
      see all


    This product has been referenced in:

    • Tesz GJ  et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . Read more (PubMed: 17500068) »
    See 1 Publication for this product

    Customer reviews and Q&As

    1-2 of 2 Abreviews or Q&A


    Thank you for your enquiry and patience. Our source for this antibody was able to provide me with the following information. The agonistic properties of the antibody were tested in a proliferation assay with mouse thymocytes (H-thymidine uptake was measured). The test results showed that 3 ug/ml [HM102] leads to cell activation (0.3 ug/ml and 1 ug/ml did not lead to cell activation). If you have any additional questions, please contact us again.

    Read More


    We do not know of any references, although this is a very popular antibody so there are probably some which we are unaware of. We are about to set up an automatic publication update system which should help us identify and then publish references for Abcam antibodies.

    Read More

    For licensing inquiries, please contact partnerships@abcam.com

    Sign up