Overview

  • Product name

    Anti-TNFRSF14/HVEM antibody
    See all TNFRSF14/HVEM primary antibodies
  • Description

    Rabbit polyclonal to TNFRSF14/HVEM
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human TNFRSF14/HVEM (N terminal).

  • Positive control

    • Mouse thymus tissue lysate
  • General notes

     This product was previously labelled as TNFRSF14

     

Properties

Applications

Our Abpromise guarantee covers the use of ab47677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 31 kDa).
IHC-P Use a concentration of 1 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function

    Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
  • Tissue specificity

    Widely expressed, with the highest expression in lung, spleen and thymus.
  • Sequence similarities

    Contains 3 TNFR-Cys repeats.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • HVEML antibody
    • ATAR antibody
    • CD270 antibody
    • CD40 like protein precursor antibody
    • Herpes virus entry mediator A antibody
    • Herpesvirus entry mediator A antibody
    • Herpesvirus entry mediator antibody
    • Herpesvirus entry mediator ligand antibody
    • HveA antibody
    • HVEM antibody
    • HVEM L antibody
    • LIGHT antibody
    • LIGHTR antibody
    • TNFRSF14 antibody
    • TNFSF 14 antibody
    • TNR14_HUMAN antibody
    • TR2 antibody
    • Tumor necrosis factor receptor like gene2 antibody
    • Tumor necrosis factor receptor superfamily member 14 antibody
    • Tumor necrosis factor receptor superfamily member 14 precursor antibody
    • Tumor necrosis factor receptor-like 2 antibody
    see all

Images

  • ab47677 at 1µg/ml staining TNFRSF14/HVEM in mouse thymus by IHC

  • Lane 1 : Anti-TNFRSF14/HVEM antibody (ab47677) at 1 µg/ml
    Lane 2 : Anti-TNFRSF14/HVEM antibody (ab47677) at 2 µg/ml

    All lanes : Mouse thymus tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 31 kDa
    Observed band size: 24 kDa
    why is the actual band size different from the predicted?

  • Immunofluorescence of TNFRSF14/HVEM in Mouse Thymus cells using ab47677 at 10 ug/ml.

References

This product has been referenced in:

  • Lan X  et al. Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis. Onco Targets Ther 10:919-926 (2017). Read more (PubMed: 28243127) »
  • Pilling D  et al. Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands. BMC Immunol 18:30 (2017). Read more (PubMed: 28619036) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab47677.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up