Anti-TNFSF18/GITRL antibody (ab25948)

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Western blot - Anti-TNFSF18/GITRL antibody (ab25948)
  • Immunocytochemistry/ Immunofluorescence - Anti-TNFSF18/GITRL antibody (ab25948)

Key features and details

  • Rabbit polyclonal to TNFSF18/GITRL
  • Suitable for: ICC/IF, WB
  • Reacts with: Human, Recombinant fragment
  • Isotype: IgG

Get better batch-to-batch reproducibility with a recombinant antibody

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Anti-TNFSF18/GITRL antibody [YGL386] (ab245694)
  • Research with confidence – consistent and reproducible results with every batch
  • Long-term and scalable supply – powered by recombinant technology for fast production
  • Success from the first experiment – confirmed specificity through extensive validation
  • Ethical standards compliant – production is animal-free

Overview

  • Product name

    Anti-TNFSF18/GITRL antibody
    See all TNFSF18/GITRL primary antibodies

  • Description

    Rabbit polyclonal to TNFSF18/GITRL

  • Host species

    Rabbit

  • Specificity

    ab25948 recognises GITRL.

  • Tested applications

    Suitable for: ICC/IF, WBmore details

  • Species reactivity

    Reacts with: Human, Recombinant fragment

  • Immunogen

    Recombinant full length protein corresponding to Human TNFSF18/GITRL. Purified.

  • Positive control

    • WB: THP-1 cell lysate.

  • General notes

    Protein previously known as TNFSF18.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab25948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
Use a concentration of 10 µg/ml.
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 20 kDa).
Notes
ICC/IF
Use a concentration of 10 µg/ml.
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 20 kDa).

Target

  • Function

    Cytokine that binds to TNFRSF18/AITR/GITR. Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues.

  • Tissue specificity

    Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

  • Sequence similarities

    Belongs to the tumor necrosis factor family.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • Activation inducible TNF related ligand antibody
      • Activation-inducible TNF-related ligand antibody
      • AITR ligand antibody
      • AITRL antibody
      • GITR ligand antibody
      • GITRL antibody
      • Glucocorticoid induced TNF related ligand antibody
      • Glucocorticoid induced TNFR related protein ligand antibody
      • Glucocorticoid-induced TNF-related ligand antibody
      • hGITRL antibody
      • MGC138237 antibody
      • TL6 antibody
      • TNF18_HUMAN antibody
      • TNFSF18 antibody
      • TNLG2A antibody
      • Tumor necrosis factor (ligand) superfamily member 18 antibody
      • Tumor necrosis factor ligand 2A antibody
      • Tumor necrosis factor ligand superfamily member 18 antibody
      see all

    Images

    • Western blot - Anti-TNFSF18/GITRL antibody (ab25948)
      Western blot - Anti-TNFSF18/GITRL antibody (ab25948)
      All lanes : Anti-TNFSF18/GITRL antibody (ab25948) at 1 µg/ml

      Lane 1 : 5 ng of purified recombinant TNFSF18/GITRL
      Lane 2 : 25 ng of purified recombinant TNFSF18/GITRL
      Lane 3 : 50 ng of purified recombinant TNFSF18/GITRL

      Predicted band size: 20 kDa

    • Immunocytochemistry/ Immunofluorescence - Anti-TNFSF18/GITRL antibody (ab25948)
      Immunocytochemistry/ Immunofluorescence - Anti-TNFSF18/GITRL antibody (ab25948)

      ab25948 at 10 µg/ml staining TNFSF18/GITRL in THP-1 cells by ICC/IF.

    References (1)

    Publishing research using ab25948? Please let us know so that we can cite the reference in this datasheet.

    ab25948 has been referenced in 1 publication.

    • Gao J  et al. The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model. Drug Dev Res 82:115-122 (2021). PubMed: 32820830

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