Overview

  • Product name

  • Description

    Rabbit polyclonal to TNIP1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human TNIP1 aa 586-636. The exact sequence is proprietary. NP_001239319.1
    Database link: Q15025

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab245536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 72 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal (By similarity). Increases cell surface CD4(T4) antigen expression. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.
    • Tissue specificity

      Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain.
    • Cellular localization

      Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
    • Information by UniProt
    • Database links

    • Alternative names

      • ABIN 1 antibody
      • HIV-1 Nef-interacting protein antibody
      • hVAN antibody
      • KIAA0113 antibody
      • Naf1 antibody
      • Nef-associated factor 1 antibody
      • Nip40-1 antibody
      • TNFAIP3 interacting protein 1 antibody
      • TNFAIP3-interacting protein 1 antibody
      • TNIP-1 antibody
      • Tnip1 antibody
      • TNIP1_HUMAN antibody
      • VAN antibody
      • Virion-associated nuclear shuttling protein antibody
      see all

    Images

    • All lanes : Anti-TNIP1 antibody (ab245536) at 0.4 µg

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 72 kDa


      Exposure time: 3 minutes


      Prepared using NETN lysis buffer.

    References

    ab245536 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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