Overview

  • Product name

  • Description

    Rabbit polyclonal to TNNC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Chicken, Cow, Pig, Quail
  • Immunogen

    Recombinant full length protein corresponding to Human TNNC1 aa 1-161.
    Sequence:

    MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E


    Database link: P63316

  • Positive control

    • Skeletal Muscle (Mouse) Whole Cell Lysate (ab3869) can be used as a positive control in WB. Mouse heart, lung or skeletal muscle lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab180732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

WB 1/500 - 1/2000. Predicted molecular weight: 18 kDa.

Target

  • Function

    Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • Involvement in disease

    Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of cardiomyopathy familial hypertrophic type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities

    Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cardiac troponin C antibody
    • CMD1Z antibody
    • CMH13 antibody
    • slow skeletal and cardiac muscles antibody
    • Slow twitch skeletal/cardiac muscle troponin C antibody
    • TN-C antibody
    • TNC antibody
    • TNNC antibody
    • Tnnc1 antibody
    • TNNC1 troponin C type 1 (slow) antibody
    • TNNC1_HUMAN antibody
    • Troponin C antibody
    • troponin C type 1 (slow) antibody
    • Troponin C, slow skeletal and cardiac muscles antibody
    • Troponin C1, slow antibody
    see all

Images

  • Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab180732. Blue DAPI for nuclear staining.
  • All lanes : Anti-TNNC1 antibody (ab180732) at 500 µg/ml

    Lane 1 : Mouse heart lysate
    Lane 2 : Mouse lung lysate
    Lane 3 : Mouse skeletal muscle lysate

    Predicted band size: 18 kDa

References

ab180732 has not yet been referenced specifically in any publications.

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