Key features and details
- Mouse monoclonal [C5] to TNNC1
- Suitable for: WB
- Reacts with: Mouse, Human, Pig
- Isotype: IgG1
Product nameAnti-TNNC1 antibody [C5]
See all TNNC1 primary antibodies
DescriptionMouse monoclonal [C5] to TNNC1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human, Pig
Recombinant full length protein corresponding to Human TNNC1 aa 1-161. Two N-terminal Tags, His-tag and GST-tag. (Expressed in E.coli).
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQ NPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDL FRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDY DEFLEFMKGVE
Database link: P63316
- WB: Recombinant human TNNC1 protein; Human lung lysate; Pig heart and skeletal muscle lysate; Mouse heart tissue.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityProtein A/G purified
Purification notesPurified from TCS.
Light chain typekappa
Our Abpromise guarantee covers the use of ab239578 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 5 µg/ml.|
FunctionTroponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Involvement in diseaseDefects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNC1 are the cause of cardiomyopathy familial hypertrophic type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Sequence similaritiesBelongs to the troponin C family.
Contains 4 EF-hand domains.
- Information by UniProt
- Cardiac troponin C antibody
- CMD1Z antibody
- CMH13 antibody
All lanes : Anti-TNNC1 antibody [C5] (ab239578) at 3 µg/ml
Lane 1 : Human lung tissue lysate
Lane 2 : Pig heart tissue lysate
Lane 3 : Pig skeletal muscle tissue lysate
Lane 4 : Mouse heart tissue lysate
All lanes : HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution
Anti-TNNC1 antibody [C5] (ab239578) at 5 µg/ml + Recombinant human TNNC1 protein
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab239578 has not yet been referenced specifically in any publications.