Overview

  • Product name
  • Description
    Rabbit polyclonal to TNR
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Cow, Human
  • Immunogen

    Recombinant fragment corresponding to a region within internal sequence amino acids 762-1023 of Human TNR (Uniprot ID: Q92752).

  • Positive control
    • Mouse brain whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab155034 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 150 kDa.

Target

  • Function
    Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.
  • Tissue specificity
    Brain specific.
  • Sequence similarities
    Belongs to the tenascin family.
    Contains 5 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 9 fibronectin type-III domains.
  • Domain
    The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B.
  • Post-translational
    modifications
    Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Janusin antibody
    • MGC149328 antibody
    • Restrictin antibody
    • Tenascin R (restrictin, janusin) antibody
    • Tenascin-R antibody
    • TENR_HUMAN antibody
    • TN-R antibody
    • Tnr antibody
    see all

Images

  • Anti-TNR antibody (ab155034) at 1/500 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 150 kDa



    5% SDS PAGE

References

ab155034 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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