Overview

  • Product name

  • Description

    Rabbit polyclonal to TNR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human TNR (internal sequence). NP_003276.
    Database link: Q92752

  • Positive control

    • Human brain and tonsil tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab198863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.
  • Tissue specificity

    Brain specific.
  • Sequence similarities

    Belongs to the tenascin family.
    Contains 5 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 9 fibronectin type-III domains.
  • Domain

    The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B.
  • Post-translational
    modifications

    Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Janusin antibody
    • MGC149328 antibody
    • Restrictin antibody
    • Tenascin R (restrictin, janusin) antibody
    • Tenascin-R antibody
    • TENR_HUMAN antibody
    • TN-R antibody
    • Tnr antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling TNR with ab198863 at 1/60 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling TNR with ab198863 at 1/60 dilution.

References

ab198863 has not yet been referenced specifically in any publications.

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