TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (ab141578)

Overview

  • Product name

    TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor.
  • Description

    Potent, reversible and competitive acetyl-CoA carboxylase inhibitor.
  • Biological description

    Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
    Hypolipidemic agent, active in vivo. Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    54857-86-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Tetradecoxyfuran-2-carboxylic acid
  • Molecular weight

    324.50
  • Molecular formula

    C19H32O4
  • PubChem identifier

    115175
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Guseva NV  et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther 12:80-5 (2011). Read more (PubMed: 21525791) »
  • Arbeeny CM  et al. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J Lipid Res 33:843-51 (1992). Read more (PubMed: 1512511) »
  • Halvorson DL & McCune SA Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid. Lipids 19:851-6 (1984). Read more (PubMed: 6549204) »
  • Parker RA  et al. 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids. J Med Chem 20:781-91 (1977). Read more (PubMed: 406395) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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