Non-selective, competitive α-adrenoceptor antagonist. Histamine H1 receptor agonist. Reverses drug-induced vasoconstriction and shows vasodilatory effects in vivo. Orally active.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Casbeer HC & Knych HK Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. Vet J196:504-9 (2013).
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Yokota S et al. Effects of imidazoline and nonimidazoline alpha-adrenergic agents, including xylazine, medetomidine, yohimbine, tolazoline, and atipamezole, on aggregation of bovine and equine platelets. Am J Vet Res74:395-402 (2013).
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Hubbell JA & Muir WW Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole. Equine Vet J38:238-41 (2006).
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