Overview

  • Product name

    Tolfenamic acid, Non steroidal anti-inflammatory agent
  • Description

    Non steroidal anti-inflammatory agent
  • Biological description

    Non steroidal anti-inflammatory agent. COX-2 inhibitor. Inhibits proliferation (IC50 = 41.5 and 52.5 μM in BT474 and SKBR3 cells) and displays anticarcinogenic activity. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    13710-19-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(3-Chloro-2-methylanilino)benzoic acid
  • Molecular weight

    261.70
  • Molecular formula

    C14H12ClNO2
  • PubChem identifier

    610479
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Basha R  et al. Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. Front Biosci (Schol Ed) 3:797-805 (2011). Read more (PubMed: 21196413) »
  • Liu X  et al. The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. Mol Cancer Ther 8:1207-17 (2009). Read more (PubMed: 19435870) »
  • Lascelles BD  et al. Nonsteroidal anti-inflammatory drugs in cats: a review. Vet Anaesth Analg 34:228-50 (2007). Read more (PubMed: 17451496) »
  • Eskerod O Gastrointestinal tolerance studies on tolfenamic acid in humans and animals. Pharmacol Toxicol 75 Suppl 2:44-8 (1994). Read more (PubMed: 7816780) »

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