Anti-Tollip antibody (ab37155)
Key features and details
- Rabbit polyclonal to Tollip
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
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Product name
Anti-Tollip antibody
See all Tollip primary antibodies -
Description
Rabbit polyclonal to Tollip -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Synthetic peptide corresponding to 16 amino acids near to the C terminus of the human Tollip protein.
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Positive control
- WB: Rat brain cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab37155 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa).
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| Notes |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa). |
Target
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Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. -
Sequence similarities
Belongs to the tollip family.
Contains 1 C2 domain.
Contains 1 CUE domain. -
Post-translational
modificationsPhosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 361677 Rat
- SwissProt: A2RUW1 Rat
- Unigene: 137040 Rat
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Alternative names
- Adapter protein antibody
- FLJ33531 antibody
- IL 1RAcPIP antibody
see all
Images
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Western blot - Anti-Tollip antibody (ab37155)Lane 1 : Anti-Tollip antibody (ab37155) at 1 µg/ml
Lane 2 : Anti-Tollip antibody (ab37155) at 2 µg/ml
All lanes : Rat brain cell lysate
Predicted band size: 30 kDa
Observed band size: 30 kDa
Protocols
Datasheets and documents
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Datasheet download
References (3)
ab37155 has been referenced in 3 publications.
- Zhi H et al. Tollip Negatively Regulates Vascular Smooth Muscle Cell-Mediated Neointima Formation by Suppressing Akt-Dependent Signaling. J Am Heart Assoc 7:N/A (2018). PubMed: 29887521
- Iyer RP et al. Defining the sham environment for post-myocardial infarction studies in mice. Am J Physiol Heart Circ Physiol 311:H822-36 (2016). PubMed: 27521418
- Vartanian KB et al. LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury. J Neuroinflammation 8:140 (2011). WB . PubMed: 21999375
