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Dear Support Group,
One of our customers needs an antibody to demonstrate the:
Fusion protein; CRTC 1 joined to MAML 2
Below her request
The translocation t(11;19) resulting in a CRTC1-MAML2 oncogene has prognostic implications in mucoepidermoid carcinomas. This translocation can be demonstrated by FISH on formalin fixed paraffin embedded tissue. There has been some publications recently that the fusion protein of this oncogene (translocation) can be demonstrated by immunohistochemistry on formalin fixed paraffin embedded tissue. The latter a cheaper and easier option.
I want to demonstrate the protein expression of the oncogene on FFPE tissue. I'm not sure whether the anti CRTC1 antibodies available on the market demonstrates the oncogene protein or the normal CRTC1 protein.
Do you have such an antibody? I cannot find one.
Thank you for your help.
Asked on Nov 09 2012
Thank you for your enquiry and your interest in our products.
We are not aware if any of our antibodies to TORC1 (CRTC1) have been involved in such scientific investigations. If they were, then the publication list of the on-line datasheet would have the specific scientific paper cited.
Currently, we have a few antibodies (TORC1) which have been tested for IHC-P such as ab109736, ab114974, ab115330 but we do not have any information regarding their suitability for FISH.
However, the good news is that we have a special offer for rabbit monoclonal antibodies (Rabmab) in November and ab109736 is a Rabmab so it would apply for this promotion (free vial). You may wish to discuss it with your customer and read the follwoing webpage for further details.
If you need any further assistance in the future, please do not hesitate to contact me.
Answered on Nov 09 2012