Overview

  • Product name

    Torin 2, mTOR inhibitor
  • Description

    Potent, selective mTOR inhibitor
  • Alternative names

    • Torin2
  • Biological description

    Potent, selective, ATP-competitive mTOR inhibitor. Inhibits mTORC1 (IC50 = 2.1 nM) in in vitro kinase activity assays. Displays 800-fold selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Attenuates phosphorylation of mTOR downstream targets, inhibits cell proliferation of several cancer cell types, and induces apoptosis and autophagy. Also exhibits potent biochemical and cellular activity against phosphatidylinositol-3 kinase-like kinase (PIKK) family kinases including ATM, ATR and DNA-PK (EC50 values are 28 nM, 35 nM and 118 nM respectively). Has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to Torin 1 (ab218606).

  • Purity

    > 98%
  • CAS Number

    1223001-51-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
  • Molecular weight

    432.40
  • Molecular formula

    C24H15F3N4O
  • PubChem identifier

    51358113
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Simioni C  et al. Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 5:10034-47 (2014). Read more (PubMed: 25296981) »
  • Zullo AJ  et al. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. BMC Biochem 15:4 (2014). Read more (PubMed: 24528777) »
  • Liu Q  et al. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res 73:2574-86 (2013). Read more (PubMed: 23436801) »
  • Liu Q  et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J Med Chem 54:1473-80 (2011). Read more (PubMed: 21322566) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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