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    toso-antibody-ab168968.pdf

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Cell Biology Apoptosis Extracellular Signals Death Ligands
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Anti-TOSO antibody (ab168968)

  • Datasheet
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Western blot - Anti-TOSO antibody (ab168968)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (ab168968)

Key features and details

  • Mouse polyclonal to TOSO
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Mouse IgG H&L (HRP) (ab205719)

View more associated products

Overview

  • Product name

    Anti-TOSO antibody
    See all TOSO primary antibodies
  • Description

    Mouse polyclonal to TOSO
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human TOSO aa 1-390.
    Sequence:

    MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCR EMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSG VYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQM PAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDK PRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQ GFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQ RPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVS ESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA


    Database link: NP_005440.1
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Human tonsil tissue; TOSO transfected 293T cell lysate.
  • General notes

     This product was previously labelled as FAIM3

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Constituent: 100% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Extracellular Signals
    • Death Ligands
    • Cell Biology
    • Apoptosis
    • Intracellular
    • Survivin / IAPs

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG - Isotype Control (ab37355)

Applications

Our Abpromise guarantee covers the use of ab168968 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.
IHC-P Use a concentration of 3 µg/ml.

Target

  • Function

    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • Tissue specificity

    Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells.
  • Sequence similarities

    Contains 1 Ig-like (immunoglobulin-like) domain.
  • Domain

    The Ig-like domain is required for the anti-apoptotic ability.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession O60667 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 9214 Human
    • Omim: 606015 Human
    • SwissProt: O60667 Human
    • Unigene: 58831 Human
    • Unigene: 728324 Human
    • Alternative names

      • Faim3 antibody
      • FAIM3_HUMAN antibody
      • Fas apoptotic inhibitory molecule 3 antibody
      • Fc fragment of IgM receptor antibody
      • Fc mu receptor antibody
      • FCMR antibody
      • IgM Fc receptor antibody
      • Immunoglobulin mu Fc receptor antibody
      • Regulator of Fas induced apoptosis antibody
      • Regulator of Fas-induced apoptosis Toso antibody
      • TOSO antibody
      see all

    Images

    • Western blot - Anti-TOSO antibody (ab168968)
      Western blot - Anti-TOSO antibody (ab168968)
      All lanes : Anti-TOSO antibody (ab168968) at 1 µg/ml

      Lane 1 : TOSO transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 15 µl per lane.

      Secondary
      All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

      Predicted band size: 43 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (ab168968)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (ab168968)

      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling TOSO with ab168968 at 3 μg/ml.

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab168968? Please let us know so that we can cite the reference in this datasheet.

    ab168968 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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