Toyocamycin, IRE1alpha inhibitor. Adenosine analog. (ab146171)

Overview

  • Product name

    Toyocamycin, IRE1alpha inhibitor. Adenosine analog.
  • Description

    Selective IRE1α inhibitor. Adenosine analog.
  • Biological description

    Selective IRE1α inhibitor. Adenosine (ab120498) analog. PI3-kinase inhibitor. Inhibits RNA self-cleavage. Induces apoptosis in cancer cell lines. Suppresses thapsigargin-, tunicamycin- and 2-deoxyglucose-induced XBP1 mRNA splicing. Shows antitumor and antimicrobial effects in vivo.
  • CAS Number

    606-58-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    291.26
  • Molecular formula

    C12H13N5O4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    c1c(c2c(ncnc2n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C#N
  • Source

    Streptomyces rimosus

References

This product has been referenced in:

  • Chien W  et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget 5:4881-94 (2014). Read more (PubMed: 24952679) »
  • Ri M  et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J 2:e79 (2012). Read more (PubMed: 22852048) »
  • Wright JM  et al. Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine. Parasitol Res 107:847-53 (2010). Read more (PubMed: 20532912) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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