• Product name
  • Description
    Rabbit polyclonal to TPC2
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human TPC2 (N terminal).

  • Positive control
    • MCF7 cell lysate, Human fetal small intestine tissue.
  • General notes

    Protein previously labeled as Two pore calcium channel protein 2.


  • Form
    Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 99% PBS, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab119915 is purified by a peptide affinity column.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab119915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 98 kDa (predicted molecular weight: 85 kDa).
IHC-P 1/100 - 1/500.


  • Function
    Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
  • Tissue specificity
    Widely expressed. Expressed at high level in liver and kidney.
  • Sequence similarities
    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
  • Domain
    Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
  • Cellular localization
    Lysosome membrane. Only the acidic lysosomal fraction is sensitive to NAADP.
  • Information by UniProt
  • Database links
  • Alternative names
    • SHEP10 antibody
    • TPC2 antibody
    • TPC2_HUMAN antibody
    • tpcn2 antibody
    • Two pore calcium channel protein 2 antibody
    • two pore segment channel 2 antibody
    • Two-pore channel 2 antibody
    • Voltage dependent calcium channel protein TPC2 antibody
    • Voltage-dependent calcium channel protein TPC2 antibody
    see all


  • Anti-TPC2 antibody (ab119915) at 1/500 dilution + MCF7 cell lysate

    Predicted band size: 85 kDa

    The amount of protein per lane: 30ug

    PVDF membrane

    Blocking solution: 5% (W/V) skim milk, with 1 X TBST buffer

    Shake membrane at room temperature with ab119915, 1/500, for 30 minutes, then transfer to 4°C overnight.
  • ab119915 at 1/100 dilution staining TPC2 in Formalin-fixed, Paraffin-embedded Human fetal small intestine tissue by Immunohistochemistry.


ab119915 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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