TPCA 1, IkappaB kinase inhibitor (ab145522)

Overview

  • Product name

    TPCA 1, IkappaB kinase inhibitor
  • Description

    Potent, selective IκB kinase inhibitor
  • Biological description

    Potent, selective IκB kinase inhibitor (IC50 = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo.
  • Purity

    > 99%
  • CAS Number

    507475-17-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
  • Molecular weight

    279.29
  • Molecular formula

    C12H10FN3O2S
  • PubChem identifier

    9903786
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Lei Y  et al. Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway. Eur J Pharmacol 634:149-61 (2010). Read more (PubMed: 20184874) »
  • Birrell MA  et al. IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol Pharmacol 69:1791-800 (2006). Read more (PubMed: 16517756) »
  • Birrell MA  et al. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med 172:962-71 (2005). Read more (PubMed: 16002568) »

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