Overview

  • Product name

    TPCK, chymotrypsin and SMase inhibitor
  • Description

    Irreversible chymotrypsin inhibitor and SMase inhibitor
  • Biological description

    Irreversible chymotrypsin inhibitor and SMase inhibitor. Inhibits the activation of PDK1-dependent AGC kinases. Selectively inhibits RSK, Akt and S6K1. Shows antitumor effects in vivo. Centrally active.
  • Purity

    > 98%
  • CAS Number

    402-71-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
  • Molecular weight

    351.80
  • Molecular formula

    C17H18ClNO3S
  • PubChem identifier

    439647
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Anjum R  et al. TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Lett 586:3471-6 (2012). Read more (PubMed: 22967899) »
  • Sun X  et al. Ceramide from sphingomyelin hydrolysis differentially mediates mitogen-activated protein kinases (MAPKs) activation following cerebral ischemia in rat hippocampal CA1 subregion. J Biomed Res 24:132-7 (2010). Read more (PubMed: 23554623) »
  • Schmitt E  et al. The Bcl-xL and Bax-alpha control points: modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation. Biochem Cell Biol 75:301-14 (1997). Read more (PubMed: 9493953) »

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