Overview

  • Product name

    TPEN, Metal ion chelator
  • Description

    Metal ion chelator
  • Biological description

    Metal ion chelator. Decreases intracellular zinc levels. Induces apoptosis. Causes defects in oocyte maturation. Modulates hippocampal neurogenesis following seizure. Cell permeable. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    16858-02-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N,N,N',N'-Tetrakis(2-pyridinylmethyl)-1,2-ethanediamine
  • Molecular weight

    424.55
  • Molecular formula

    C26H28N6
  • PubChem identifier

    5519
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(CN(Cc1ccccn1)Cc2ccccn2)N(Cc3ccccn3)Cc4ccccn4
  • Source

    Synthetic

References

This product has been referenced in:

  • Tian X & Diaz FJ Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology 153:873-86 (2012). Read more (PubMed: 22147014) »
  • Kim JH  et al. Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure. PLoS One 7:e48543 (2012). Read more (PubMed: 23119054) »
  • Chimienti F  et al. Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochem Pharmacol 62:51-62 (2001). Read more (PubMed: 11377396) »

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