Anti-TPH2 antibody (ab125877)
Key features and details
- Rabbit polyclonal to TPH2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TPH2 antibody
See all TPH2 primary antibodies -
Description
Rabbit polyclonal to TPH2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Dog, Monkey, Zebrafish -
Immunogen
Recombinant fragment corresponding to Human TPH2 aa 178-465.
Database link: Q8IWU9 -
Positive control
- IMR32 whole cell lysate U87-MG whole cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab125877 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 56 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 56 kDa. |
Target
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Tissue specificity
Brain specific. -
Pathway
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. -
Involvement in disease
Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. -
Sequence similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain. - Information by UniProt
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Database links
- Entrez Gene: 121278 Human
- Entrez Gene: 216343 Mouse
- Entrez Gene: 317675 Rat
- Entrez Gene: 407712 Zebrafish
- Omim: 607478 Human
- SwissProt: Q8IWU9 Human
- SwissProt: Q8CGV2 Mouse
- SwissProt: Q8CGU9 Rat
see all -
Alternative names
- MGC138871 antibody
- ADHD7 antibody
- FLJ37295 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab125877 has been referenced in 1 publication.
- Huang X et al. The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis. Mol Cell Endocrinol 493:110472 (2019). PubMed: 31167113