Key features and details
- Rabbit polyclonal to TPH2
- Suitable for: WB
- Reacts with: Human, Baboon
- Isotype: IgG
Product nameAnti-TPH2 antibody
See all TPH2 primary antibodies
DescriptionRabbit polyclonal to TPH2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human, Baboon
Predicted to work with: Mouse, Rat, Chicken, Dog, Monkey, Zebrafish
Recombinant fragment corresponding to Human TPH2 aa 178-465.
Database link: Q8IWU9
- IMR32 whole cell lysate U87-MG whole cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin 300
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab125877 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 56 kDa.|
Tissue specificityBrain specific.
PathwayAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
Involvement in diseaseGenetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.
- Information by UniProt
- MGC138871 antibody
- ADHD7 antibody
- FLJ37295 antibody
ab125877 has been referenced in 1 publication.
- Huang X et al. The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis. Mol Cell Endocrinol 493:110472 (2019). PubMed: 31167113